Immunohistochemistry Kits and Reagents
ABclonal Technology Phospho-PDK1/PDPK1-S241 Rabbit pAb
Enables 3-phosphoinositide-dependent protein kinase activity, phospholipase activator activity, and phospholipase binding activity. Involved in several processes, including cell surface receptor signaling pathway, regulation of protein kinase activity, and regulation of signal transduction. Acts upstream of or within intracellular signal transduction. Located in cell projection, cytosol, and plasma membrane. Implicated in prostate cancer. Biomarker of lung non-small cell carcinoma.
Biotium CD34(ICO-115), CF594 conjugate, 0.1mg/mL
This antibody recognizes a carbohydrate epitope on a single chain, transmembrane, heavily glycosylated protein of 90-120 kDa, which is identified as CD34 (VI international workshop on human differentiation antigens). Its expression is a hallmark for identifying pluripotent hematopoietic stem or progenitor cells. Its expression is gradually lost as lineage committed progenitors differentiate. CD34 is a marker of choice for staining blasts in acute myeloid leukemia. In addition, it is expressed by soft tissue tumors, such as solitary fibrous tumor and gastrointestinal stromal tumor. CD34 expression is also found in vascular endothelium. Additionally, proliferating endothelial cells overexpress this molecule than the non-proliferating endothelial cells. Anti-CD34 labels > 85% of angiosarcoma and Kaposi's sarcoma, but shows low specificity.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness
Biotium FOXP3(FXP3/197), CF594 conjugate, 0.1mg/mL
Recognizes a protein of 47-55 kDa, which is identified as FOXP3. Its precise epitope is not known, but it has been mapped to the N-terminal portion of the protein. The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.Primary antibodies are availabl
Biotium CD45RO(UCHL-1), CF594 conjugate, 0.1mg/mL
Recognizes a 180-185 kDa protein, identified as isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion. This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B or natural killer cells, but reacts with granulocytes and monocytes. Reportedly, it is useful to identify T-cell lymphomas and leukemias. It rarely stains NK cells or B-cell lymphomas.Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like CF405S and CF405M are not recommended for detecting low abundance targets, because blue dyes have lower fluorescence and can give higher non-specific background than other dye colors.
Biocare Medical, LLC Pan Melanoma + Ki-67 Antibody - Predilute, 6.0 ml
Pan Melanoma Antibody Ki-67 serves as a tool to identify the proliferation rate of melanocytic lesions in cases in which melanocytes are sparse; there are dense lymphocytic infiltrates; and melanocytes are admixed with fibroblasts. In general, a higher proliferative fraction is seen in melanoma than in melanocytic nevi. There are many types of nevi, and some simulate melanoma closely. If the Multiplex stain shows a very low Ki-67 (DAB) labeling rate in MART-1/Tyrosinase positive cells (Fast Red), this favors benignity. A high rate, especially toward the deep part of a melanocytic lesion raises the possibility of malignancy.
Surmodics Inc Alkaline Phosphatase/Horseradish Peroxidase Block, 100mL
BioFX™ Alkaline Phosphatase/Horseradish Peroxidase Block is supplied as a ready-to-use blocking reagent for immunohistochemistry samples. The solution blocks both alkaline phosphatase and peroxidase endogenous enzymatic activity.
ABclonal Technology SYNPO Rabbit pAb
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the proteins associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).
ABclonal Technology SYNPO Rabbit pAb
Synaptopodin is an actin-associated protein that may play a role in actin-based cell shape and motility. The name synaptopodin derives from the proteins associations with postsynaptic densities and dendritic spines and with renal podocytes (Mundel et al., 1997 [PubMed 9314539]).
Biotium Uroplakin 1A (Urothelial Differentiation Marker)(UPK1A/2924), CF740 conjugate, 0.1mg/mL
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The protein may also play a role in tumor suppression. Primary antibodies are available purified, or with a selection of fluorescent CF Dyes and other labels. CF Dyes offer exceptional brightness and photostability. Note: Conjugates of blue fluorescent dyes like
Meridian Life Science Lyo-Ready Direct RNA/DNA, 1ML
Lyo-Ready RNA/DNA LAMP Saliva mix combines even greater tolerance with fast, robust isothermal amplification to enable highly sensitive direct detection using crudely processed saliva or sputum samples. The mix is uniquely designed to overcome much higher concentrations of inhibitors, and so do not require a DNA or RNA purification step to concentrate and purify a patient sample. Very fast reaction kinetics result in faster time to results and superior amplification sensitivity and specificity. In addition, the 4x concentrated master mix is formulated with lyo-excipients which are optimized for freeze-drying to create ambient-temperature stable assays, making it ideal for POC saliva testing.
Meridian Life Science Lyo-Ready Direct RNA/DNA, 500ML
Lyo-Ready RNA/DNA LAMP Saliva mix combines even greater tolerance with fast, robust isothermal amplification to enable highly sensitive direct detection using crudely processed saliva or sputum samples. The mix is uniquely designed to overcome much higher concentrations of inhibitors, and so do not require a DNA or RNA purification step to concentrate and purify a patient sample. Very fast reaction kinetics result in faster time to results and superior amplification sensitivity and specificity. In addition, the 4x concentrated master mix is formulated with lyo-excipients which are optimized for freeze-drying to create ambient-temperature stable assays, making it ideal for POC saliva testing.
Meridian Life Science Lyo-Ready LAMP Mix 4x, 5ML
Lyo-Ready LAMP Mix 4x is a glycerol-free mix for use in loop-mediated isothermal amplification (LAMP). It combines the latest advances in buffer chemistry and reaction enhancers, together with an optimized concentration of strand-displacing Polymerase, dNTP and proprietary lyo-excipients allowing ambient temperature stabilization through lyophilization. Lyo-Ready LAMP Mix has been designed for fast, sensitive and highly reproducible DNA target amplification. In order to produce lyophilized ambient-temperature stable LAMP assays, specific primers need to be added prior to lyophilization.
Abcam Mouse and Rabbit Specific HRP/DAB IHC Detection Kit - Micro-polymer, 60ML
Rabbit/mouse dual, HRP/DAB detection IHC kit is a colorimetric micro-polymer assay kit used to detect mouse and rabbit primary antibodies in immunohistochemistry (IHC). - Cited in over 65 publications - No need for endogenous biotin blocking - Includes ready-to-use blocking reagents - Higher sensitivity than streptavidin-biotin methods
The product is subject to the following: Abcam Restricted Use Statement
Leica Biosystems Bond Enzyme Pretreatment Kit
BOND ancillaries have been designed for Leica Biosystems fully-automated BOND systems: BOND-MAX and BOND-III systems. Used in the development and validation of BOND ready-to-use primary antibodies and ISH probes - choose Leica Biosystems reagents for the assurance of a quality result in your laboratory.BOND Enzyme Pretreatment Kit consists of an enzyme concentrate and an enzyme diluent, which require mixing. The enzyme is diluted before use in the BOND Open Containers supplied. The diluted enzyme solution is used for enzymatic digestion on the automated BOND system.